There are quite a few issues with the translation of this article, namely the section that talks about emulation, cases of poor wording and nonsense translation can be seen.
"The developers note that the significant issues are due to the x86_x64 CPU instructions of the open-source architecture. Almost all apps and games rely on specific instructions, and when they need to run on another architecture, those instructions need to be substituted or duplicated."
Is one of those cases, I believe a more accurate statement would be:
"The developers note that the x86_64 instruction set used by the game is a significant issue for the open-source architecture. Almost all apps and games rely on architecture specific instruction sets, and when they need to run on another architecture, those instructions need to be emulated."
More and more companies have started to introduce RISC-V products, but there isn't much focus on gaming with these open-source CPUs, mostly due to compatibility issues. But that didn't stop Box86/Box64 developers from running The Witcher 3 on Milk-V Pioneer paired with an AMD Radeon RX 5500 XT.